- Title
- Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness
- Creator
- Aucoin, Rachelle; Lewthwaite, Hayley; Ekström, Magnus; von Leupoldt, Andreas; Jensen, Dennis
- Relation
- Respiratory Physiology & Neurobiology Vol. 311, Issue May 2023, no. 104036
- Publisher Link
- http://dx.doi.org/10.1016/j.resp.2023.104036
- Resource Type
- journal article
- Date
- 2023
- Description
- Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated that TGN stimulation activated 12 brain regions widely implicated in the anticipation and/or perception of breathlessness, including the insular cortex and amygdala. Inhaled L-menthol or cool air to the face activated 75% and 33% of these 12 brain regions, respectively. Our findings support the hypothesis that TGN stimulation contributes to breathlessness relief by altering the activity of brain regions involved in its central neural processing.
- Subject
- trigeminal nerve; olfactory nerve; breathlessness; eural activity; L-menthol; cool air
- Identifier
- http://hdl.handle.net/1959.13/1489043
- Identifier
- uon:52602
- Identifier
- ISSN:1569-9048
- Language
- eng
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